Point of Care Enabled Precision Medicine
Driven from the convergence of Advanced Cell Engineering with Transformational Procedural Innovations
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The real challenge with cancer

Solid Tumors is the Largest Market Opportunity in Cancer but Mostly Unaddressed with Advanced Precision Medicine

Solid Tumors have escape mechanisms

Hide behind dense matrix (tumor micro environment)
Secrete factors inhibiting immune response

Solid Tumors are complex

Often detected when metastasis have taken hold
Metastasis often responds differently to therapy

Innovative Therapies are difficult to manufacture

Advanced cell therapies are expensive
Not ready when patient is ready: Long manufacturing lead time

Breaking Through

Tidewave innovations are Designed to Overcome the Major Barriers to Make Cost-Effective Cell Therapy Available Broadly to Solid Tumor Patients

ENHANCED POTENCY: Engineered cells designed to overcome tumor resistance

Activate broad immune response to enhance coordinated tumor invasion, killing and immune memory

SCALABLE MANUFACTURING:
Banked donor (allogenic) HSC-derived cells

Saves costs: Breaking through logistic complexities of autologous cell processes

RAPID PERSONALIZATION: Point-of-care enabled precision medicine

Tidewaves’ unique approach adapts its universal cell product to recognize each patient’s tumor in real time. This innovation enables precision medicine with no treatment delays, ensuring patients receive care as soon as they are diagnosed
Tidewave Biopsy Precision SYSTEM
Tidewave Biopsy Precision system Enables 4-Steps Same Day Point-of-Care Treatment

Biopsy SAMPLE

1
From the Patient

TIDEWAVe BIO CELLs

2
Stored on site

BIOPSY PRECISION SYSTEM

3
Process biopsy and combine with Tidewave Bio Cells on site

@point of care

4
Back to patient same day
Universal Precision medicine tailored at the point of care. A paradigm Shift transforming cost and patient access to life saving therapies
Our Impact

Tidewave Aims to Impact healtcare value proposition broadly

For providers and payors

  • Universal & Scalable Solution: A single, off-the-shelf cell therapy applicable to all cancer types, eliminating the need for companion diagnostics.
  • Cost & Operational Efficiency: Streamlined, point-of-care personalization reduces logistical complexities and significantly lowers treatment costs
  • Optimized Patient Flow: Immediate availability minimizes hospital stays and resource strain, improving overall healthcare efficiency.
Universal & Scalable Solution: A single, off-the-shelf cell therapy applicable to all cancer types, eliminating the need for companion diagnostics.
Cost & Operational Efficiency: Streamlined, point-of-care personalization reduces logistical complexities and significantly lowers treatment costs
Optimized Patient Flow: Immediate availability minimizes hospital stays and resource strain, improving overall healthcare efficiency.

For patients and healthcare ecosystem

Timely & Personalized Treatment: Readily stored at the point of care, ensuring no treatment delays and immediate access when needed.
Better Outcomes, Fewer Side Effects: Precision-engineered therapy tailored to individual patients, increasing efficacy while minimizing toxicity.
Accessible & Equitable Care: Eliminates barriers to advanced treatment by removing reliance on complex autologous processing and specialized facilities.

For industry and investors

• Scalable & Disruptive Model: Combines high-volume manufacturing with localized personalization, dramatically reducing cost structures.
• Strategic Market Advantage: A next-generation therapy that aligns with the growing demand for precision medicine and cell therapy innovation.
• Regulatory & Commercial Feasibility: Designed to meet global healthcare standards while supporting widespread adoption and long-term market sustainability.

Leadership

François Binette PhD,
CEO/Founder
François is a veteran executive with 30 years of experience in advanced cell and gene therapy product development across multiple therapeutic areas. His background includes leadership roles in both startups and major healthcare organizations. He previously served as President of Renovaro Biosciences, CEO of Rediens, and Global Head of Product Development at Lineage Cell Therapeutics, with prior experience at Johnson & Johnson, Medtronic, and Genzyme.
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Michael Montgomery, MD
CMO
Michael is a physician-scientist with over 25 years of experience in internal medicine, developmental biology, and drug development. He has held senior leadership roles in both biotech startups and major pharma, including Centocor, Johnson & Johnson, and Incyte. He co-founded the Proof-of-Concept Team at J&J and led Global Medical Affairs at Incyte.
David Wheland
Strategic Advisor
Dave Whelan has devoted his career to building businesses and inspiring entrepreneurs at the intersection of technology, health, and wellness. Dave works with organizations and entrepreneurs across the country and around the world, through his consultancy Bespoke Strategy, as well as collaborations with Wavemaker Three-Sixty Health and Big4Bio. He has held senior roles with BioscienceLA and New York Genome Center, among others. He hold an MBA from UCLA Anderson School and a BS Symbolic Systems from Stanford University.
“Confidential” PHD
Head Translational Science
Stealth
Saeed Sadeghi MD,
Clinical advisor
Dr. Saeed Sadeghi is a hematologist and medical oncologist in Santa Monica, specializing in breast, gynecological, and hepatobiliary cancers. Board-certified in internal medicine, hematology, and oncology, he participates in UCLA Health clinical trials and has led research on breast and hepatobiliary cancers. Dr. Sadeghi received his medical degree from the St. Louis University School of Medicine. He then completed his internal medicine residency at the Los Angeles County+USC Medical Center, followed by his hematology-oncology fellowship at UCLA.
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